Biological Age, Not Chronological Age, Is Associated with Late-Life Depression

Age-by-disease biological interactions: implications for late-life depression

Onset of depressive symptoms after the age of 65, or late-life depression (LLD), is common and poses a significant burden on affected individuals, caretakers, and society. Evidence suggests a unique biological basis for LLD, but current hypotheses do not account for its pathophysiological complexity. Here we propose a novel etiological framework for LLD, the age-by-disease biological interactio...

Only Female Age, and Not Blood Type, Is Associated with Ovarian Reserve

Frailty, fitness and late-life mortality in relation to chronological and biological age

BACKGROUND People age at remarkably different rates, but how to estimate trajectories of senescence is controversial. METHODS In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) we estimated a frailty index based on the proportion of 20 deficits observed in a structured clinical examination. The construct validity of the index was examined through its r...

Is Life Expectancy Associated with Depression in the Elderly?

Introduction: Depression is one of the most common psychiatric disorders and risk factors for suicide in aging that often underdiagnosed and those who are more hopeful, suffer from less depression. The present study was conducted to determine the relationship between life expectancy and depression among older people in Yazd, Iran.   Methods: This descriptive cross-sectional study was con...

Late-life anxiety is coming of age.

Anxiety is an adaptive human experience that may occur at all ages and serves to help draw attention to, avoid or cope with immanent threat and danger. Given its evolutionary importance, it has strong genetic and biological underpinnings, and when it serves that adaptive function for the organism, anxiety may be viewed as useful. However, complex adaptive systems, such as our adaptation to thre...